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Additionally, cases of ME/CFS have also been recorded post-immunization (163) and many patients are fearful that vaccinations will worsen their already dysfunctional immune system and cause symptom exacerbation (164)

Current therapies offer only modest symptom relief and fail to address the underlying mechanisms (6, 7) (Table 1)

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J Plant Nutr Soil Sci 182:701707 Tewari RK, Horemans N, Watanabe M, Dietz K-J (2021a) Evidence for a role of nitric oxide in iron homeostasis in plants