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Demonstrates that NNMT activity regulates adipogenesis and energy expenditure in murine models, establishing NNMT as a key metabolic enzyme target

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With respect to the endodermal lineage, the Yamanaka group observed that hiPSC lines derived from a number of different donors demonstrated a high degree of variability in terms of their capacity to differentiate to hepatocytes 25

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However, it is important to note that the treatment does not prevent the body from accumulating new fat if there are underlying dietary or lifestyle issues