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doi: 10.1016/j.jare.2023.03.008 188 PlovierHEverardADruartCDepommierCVan HulMGeurtsLet al

CNS delivery and anti-inflammatory effects of intranasally administered Cyclosporine-A in cationic nanoformulations

Nausea or transient gastrointestinal discomfort during initial dosing

Native IGF-1 exists predominantly bound to IGF-binding proteins (IGFBPs) in circulation, which sequester the growth factor and limit its bioavailability to target tissues

139,140 In addition, recently, IDH1 and IDH2 gene mutations have been prevalent in several diverse malignancies, including glioma, AML, angioimmunoblastic lymphomas, chondrosarcoma, and melanomas

[Abstract]2024 Nov 7;32(11):2013-2022.e5