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For IIH, these newly described pathways could lead to targeted weight loss therapies, such as customized bariatric surgery, or other novel therapeutics such as glucagon-like-peptide-1 (GLP-1) receptor agonists

Ideal candidates are those who may have struggled with traditional weight loss methods or who face health challenges that impact weight management

Additionally, GLP-1s decrease appetite

Transfer of the associated accession numbers into the Kyoto Encyclopedia of Genes and Genomes (KEGG) for bioinformatic analysis demonstrated a multitude of metabolic alterations, as indicated by the fold enrichment of associated pathways represented within the dataset

2025, pp

Improvement in insulin sensitivity The recent finding that GIP/GLP-1 receptor co-agonists like tirzepatide have superior efficacy compared to selective GLP-1 receptor agonists with respect to glycemic control as well as body weight has renewed interest in GIP [20], which previously was thought to be without any therapeutic potential