semaglutide after roux-en-y gastric bypass weight regain Long-term effect of sleeve gastrectomy vs in people living with severe obesity: a phase III multicentre randomised controlled trial (SleeveBypass) Guidelines for GLP-1 Therapy for

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Summary: Wegovy has no absolute upper age limit in the UK, but clinical trial data for patients aged 75 and older are limited, requiring individualised prescribing decisions based on frailty, comorbidities, and overall health status

These findings align with evidence that GLP-1 is widely expressed and secreted within the nervous system, supporting potential effects in either the central or peripheral nervous system, the researchers wrote

They found that those who took GLP-1s had a 46% lower risk of death from any cause during the follow-up period of about 5.5 years