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Directly activating GIPR in hepatocytes is an unlikely explanation for the decrease in apoC-III levels with tirzepatide [91, 92]

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doi: 10.1016/j.neuroimage.2013.06.074 90 ArevaloMAAzcoitiaIGarcia-SeguraLM

These metabolite changes suggest that the retrograde signal may involve altered activity of chromatin-modifying enzymes sensitive to these metabolites

Why GLP-1 Drugs Can Create Nutritional Problems Appetite suppression lowers total nutrient intake This is the most obvious mechanism