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Previously we showed that methimazole becomes severely hepatotoxic in enzyme-induced mice.52 This mentioned the importance of reactive metabolites in methimazoleinduced toxicity

The reasons vary from genetic factors affecting receptor sensitivity to metabolic conditions that override GLP-1 signaling to undiagnosed medical issues masking the medication effects

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Patients under chronic dialysis were also excluded

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[DOI] [PubMed] [Google Scholar] 11.Wang J., Kim C.H