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Poor sleep accelerates amyloid-beta accumulation in the brain, and pineal dysfunction is common in Alzheimer disease

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Statistical data management and analyses were performed using SAS software (version 9.4, SAS Institute Inc., Cary, NC)

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The 3DMM approach integrates information of several experimental conditions and replicates into one stoichiometry model, which uses phosphopeptide-, non-phosphorylated peptide- and corresponding protein-intensities from any multiplexed quantification method