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Knowing the underlying molecular mechanisms and patients environmental context is essential to develop effective treatments

High dose oral supplementation is an effective alternative to parenteral treatment Randomized studies of daily high oral doses of 1,0002,000 g have shown equivalence or superiority to injected B 12

Crucially, proposed targets and pathways must be validated using orthogonal methods

If youve tried these methods and are still looking at a cloudy mess, it's a clear signal to rethink your solvent

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