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Purified stem cells from apical papilla (SCAPs) were seeded at 1 10 4 cells/mL into 10 cm culture dishes and cultured in alpha minimum essential medium (-MEM, Gibco, Life Technologies, Grand Island, NY) supplemented with 6% fetal bovine serum (Gibco, USA), 100 U/mL penicillin and 100 g/mL streptomycin at 37 C in 5% CO 2

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This, however, was followed by systematic reviews showing inconsistent results and hence raised questions on replicability (Table 7)

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