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Tacrolimus: A prospective study in healthy Chinese volunteers (N=9) with CYP3A5 expressers showed a 2.5-to 4-fold increase in tacrolimus exposure when concomitantly administered with amlodipine compared to tacrolimus alone

Int J Mol Sci 23:6139

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This does not mean the risk is equal or that newer medications are more dangerous

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A major effort in this study was the collection of urine samples from 27 and 17 endangered leopard cats in two islands where there are only about 100 individuals each