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Oxygen-ozone (OO) therapy, an intervention that activates NRF2, increases SOD, catalase, and HO-1, while suppressing pro-inflammatory cytokines (IL-6, TNF-, IL-1) (33)

The Rome IV criteria define IBS as chronic or recurrent abdominal pain associated with altered bowel habits

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After 3 to 4 months on tirzepatide, if its specific side effects (perhaps insomnia or different GI patterns) become problematic, returning to semaglutide allows your body to reset from tirzepatide-specific effects

In this model, iodine deficiency and Se deficiency exacerbate H2O2 accumulation, Se deficiency decreases cellular defense, promotes thyroid cell fibrosis, increases the inflammatory response following thyroid cell necrosis, and thiocyanate overload triggers follicular cell necrosis