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In PD, a ketogenic diet trial (very high fat, low carbohydrate) is underway, hypothesizing shifts in the microbiome/metabolome (elevated ketones and possibly Akkermansia ) with potential motor benefits [236]

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The efficacy of lorcaserin appears similar to that of orlistat (mean difference in weight loss between active and placebo treated groups approximately 3 to 4 kg) and perhaps slightly less than that of phentermine-topiramate

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The most common side effects include nausea, diarrhea, vomiting, constipation, headache, fatigue, and dizziness

Mutating this residue to an alanine shows a similar increase in carnitine K M as the mutants above (Fig