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Some formulations may include stabilizing excipients used during freeze-drying to help maintain peptide integrity

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A meta-analysis by Lee et al

Limitations and future directions As with any animal study, the limitation of the current study is the application of its findings to human settings, which is challenging due to both obvious and subtle distinctions between humans and animals

Experimental investigations from cellular cultures found the activation of NRF-2 by high doses of glucose, but there was variability between type of cellular pedigree and time of exposure [9193]