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The lipid tail allows retatrutide to bind serum albumin, which slows clearance and gives the peptide a half-life long enough for once-weekly dosing in published animal pharmacokinetic work
In contrast to other proteins that do not engage FcRn, the two ligands are prevented from progressing to the lysosomes for degradation by binding to the receptor in early sorting endosomes 41,43,47,49,50
doi: 10.1016/j.molmet.2022.101533 128 GaultVABhatVKIrwinNFlattPRGaultVABhatVKet al
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Retatrutide is administered once weekly via subcutaneous injection
& Valverde, I
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