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Similar to albumin, AAT can function as an indirect free radical scavenger by interacting with neutrophil alpha defensins, 159-161 free fatty acids, 162 and free heme

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Metabolites from fatty acid metabolism, such as ketone bodies and SCFAs, are vital in regulating neuroimmune responses ( -3 fatty acids are well-established (44, 45), attributed mainly to (1) their conversion into pro-resolving mediators like lipid regulators, resolvins, and anti-inflammatory mediators, which inhibit pro-inflammatory factors like TNF-a, IL-1, and NF-B, and (2) the inhibition of -6 fatty acids from converting into pro-inflammatory substances like prostaglandins (PG) E2 and leukotrienes (LT) B4