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A consistent finding across this body of work is BPC-157s capacity to accelerate healing timelines and reduce inflammatory markers, effects attributed to its interaction with the NO system (both the constitutive NOS and inducible NOS pathways) and its promotion of angiogenesis through upregulation of VEGF expression

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Unlike oral agents (e.g., gabapentin, duloxetine) that suffer from systemic side effects and variable bioavailability, or injectables (e.g., insulin, lidocaine) that require invasive administration, microneedles enable localised, minimally invasive, and patient-friendly drug delivery [105]