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This research grant was co-jointly funded by Whiteley Corporation

Proc Natl Acad Sci USA 106(41):1751117516 Zhu B et al (2017) Knockout of the Nogo-B gene attenuates tumor growth and metastasis in hepatocellular carcinoma

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Therefore, the anaplerotic flow between the glutamate-glutamine cycle and the citric acid cycle, mediated by the pyruvate carboxylase enzyme, has been proposed to have detoxification capacities.63 Comparing the susceptibility to morphologic and functional changes of the astroglial and microglial cells under hyperammonemic conditions, astrocytes are more susceptible.64 The capacity of ammonia to free proinflammatory substances on the part of the microglia has also been studied in that context

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