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Mechanism of Action: Why It Makes Sense for Athletes Sermorelin binds to GHRH receptors in the anterior pituitary, increasing pulsatile GH release and downstream insulin-like growth factor-1 (IGF-1) production. Growth hormone and IGF-1 influence several systems relevant to performance: Protein synthesis and muscle repair Collagen formation and tendon remodeling Lipolysis and metabolic efficiency Sleep architecture, particularly slow-wave sleep Because GH secretion is naturally highest during deep sleep, sermorelin is typically administered at night to align with this physiology

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The amount of homocysteine in the blood is regulated by at least four vitamins: folate, vitamin B 6 , riboflavin, and vitamin B 12 (see Figure 1 )