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October 20, 2023
In hypertension, GLP-1 attenuates the excitability of carotid body cells diminishing sympathetic activation, augments renal blood flow to promote natriuresis and diuresis as well as facilitates generation of nitric oxide in vascular smooth muscle cells
The availability of both weekly injectable and daily oral formulations further broadens its reach across diverse patient and prescriber segments
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These medications' effects on gastric function create important considerations for patients scheduled to undergo colonoscopy or other endoscopic procedures
One study, EMPA-KIDNEY, was more broadly based, and included people who were minimally proteinuric (ACR 65 years, glycated hemoglobin (A1C) 7%, baseline eGFR 30 mL/min per 1.73 m, or uACR 30 mg/mmol [72]
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