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PMC 310948

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The ACG IBS guideline conditionally recommends against probiotics for global IBS symptoms

However, much of the research has illustrated that such an effect is a negation of caffeines ability to raise blood pressure rather than an ability of L-theanine to take a persons blood pressure down below its normal resting state.26 Also, in some research looking at L-theanine in isolation (or, more specifically, in mango sorbet), no effect on blood pressure was observed.27 It appears that L-theanine should be mostly safe for most people, but its always a good idea to talk to your doctor before introducing any new supplement into your regimen