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Previous studies have shown that the Box1 motif, although required for JAK binding, is not sufficient to determine the specificity for a particular JAK to associate with its cytokine receptor, and that additional sequences in the receptor play an important role in specificity since JAK1 and JAK2 were shown to have different preferences for GHR, EPOR, and GP130 chimeras (70)

When we consume a fatty meal, the gallbladder releases bile into the small intestine to aid in digestion

Human GH receptor-IGF-1 receptor interaction: implications for GH signaling

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In Drugs and Supplements

EMBO Mol Med 13:e13067