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Moreover, PHGDH upregulation confers resistance to MEK inhibitors in NRAS-mutant melanoma, whereas targeted PHGDH inhibition restores the sensitivity of resistant tumors to MAPK signaling pathway inhibitors by reducing intracellular glutathione levels and enhancing oxidative stress (89, 90)

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Hal ini tergantung dari jenis gangguan kesehatan yang sedang diobati, tingkat keparahan, serta respon tubuh seseorang terhadap penggunaan obat

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