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A subsequent multicenter Phase 2 trial in participants with overweight or obesity reported approximately 15.6% mean body weight reduction at 32 weeks with cagrilintide 2.4 mg plus semaglutide 2.4 mg, compared to roughly 5.1% with placebo and lower percentages with either monotherapy

However, the pathways behavior depends heavily on cellular context

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[1] This overlap creates a common clinical scenario where patients and healthcare providers must consider whether weight loss injections can be safely combined with ongoing sertraline therapy