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Add-on value of tirzepatide versus semaglutide

Rather than relying on willpower alone, it uses science-backed tools and professional guidance to address the factors that can make weight management difficult

Nevertheless, still, it remains unclear whether these consequences of GIP in AT or fat metabolism are defensive or deleterious chronically

GLP-1 therapies are only used as an addition, not a replacement

A new Cleveland Clinic analysis of nearly 8,000 patients suggests that discontinuing semaglutide and tirzepatide, on average, does not lead to significant weight regain in clinical practice, as many patients later restart the original medication or try an alternative obesity treatment

Psychiatry 66 , e99 (2023)