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p53-pS15 is a major focal point in p53 activation to mediate p53-dependent transcription or growth arrest, Ser 15 phosphorylation triggers a sequence of additional sites phosphorylation in p53 (including Ser9, -20, -46 and Thr18) that contribute further to p53 activation 28

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Quality and integrity of the RNA samples were assessed using a 4200 TapeStation (Agilent Technologies) and then libraries generated using the Illumina Stranded mRNA Prep

It is more likely, however, that the shared intracellular signalling pathways or the activities of hybrid receptors are responsible for the common activities of IGF-I and insulin

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