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Mechanisms of action Preclinical studies document: Anxiolytic effect without sedation in classical tests (elevated plus maze, open field, light-dark box) GABAergic system modulation : allosteric potentiation of GABA-A observed ex vivo Enkephalin increase (endogenous opioid peptide) and serotonergic modulation Immunomodulatory effects inherited from tuftsin: macrophage activation, T-helper modulation Behavioural models Anxiolysis is measured via time spent in open arms of the elevated plus maze (EPM), visit ratio of central zones of open field , and exit latency in light-dark box
Stress modulation: Research suggests proposed stress-protective and anxiolytic-like effects [4] [11]
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As the sixth entrant launches, a second reduction
Remission status is more favorable than active disease, but individual factorsfrequency of past flares, current medications, disease durationaffect risk
Nutr Neurosci 13:183188 Kume S, Yamato M, Tamura Y et al (2015) Potential biomarkers of fatigue identified by plasma metabolome analysis in rats
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