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BMJ 2016;352:i581.ArticlePubMedPMC 57

While Retatrutide wins on paper, Zepbound wins in the real world for a few key reasons: *The options weve highlighted as the winner are based on the evidence currently available

Marx N, Federici M, Schtt K et al (2023) 2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes

However, metabolic disorders are fundamentally systemic diseases driven by impaired endocrine crosstalk (Theurey and Rieusset, 2017

[] Moreover, GLP-1 inhibits the secretion of glucagon from alpha cells of pancreatic islets and as an extra-pancreatic effect, it directly shows the inhibitory responses on appetite centers and delays the gastric emptying time, which may lead to felling satiety

Furthermore, the human subject trials varied in length and dose, which makes it hard to conclude that GLP-1 use prevents muscle loss while losing fat at this time, and we dont know if exercise was a variable controlled for