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These states were captured in the presence of agonist 2S, 4R-4-methyl glutamate (SYM) 26 and antagonist UBP310 27 respectively (Supplementary Fig

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Furthermore, GSEA of all DEGs confirmed enrichment of pathways involving these 16 genes, including adaptive immune system terms, with directionality consistent with the primary pre/post-treatment comparison (Supplementary Fig