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Plowman JE, Miller RE, Thomas A et al (2021) A detailed mapping of the readily accessible disulphide bonds in the cortex of wool fibres

A vial that moves from freezer to room temperature and back again over and over may collect condensation risk and experience more stress than a vial that stays in one stable cold environment

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Again, the evidence for this is preliminary, and the research has primarily involved animal or lab studies, not human