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Those who fall short of this threshold typically remain late responders throughout treatment, achieving lower total weight loss despite continuing the protocol

doi: 10.1038/nmeth752

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Related GLP-1 podcast: Prescribing GLP-1s: Evidence, limits, expectations While it is ideal for all physicians to adopt a holistic approach in supporting patients with weight loss, this practice is not consistently implemented

For patients managing diabetes with insulin or sulfonylureas alongside GLP-1 therapy, hypoglycemia becomes a concern

Moreover, the role of variation in drug metabolizing enzymes between different individuals and its possible impact on the hepatic injury induced by these drugs is discussed here