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While the concentration of research within a single group has drawn some scientific criticism regarding independent verification, it has also produced an unusually coherent and detailed body of knowledge about a single compound

Comparatively, oral tirzepatide exists only in compounded form without FDA evaluation, raising the question, "Does oral tirzepatide work?" Current evidence emphasizes the robust performance of injections over oral alternatives

Although in silico tools can accelerate the initial ranking and prioritization of candidates, they cannot fully reproduce cellular proteolysis, the effects of non-natural amino acid modifications, or steric hindrance caused by the oligonucleotide payload attached to the peptide

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The clinical expert consulted by CADTH stated that treatment should be continued so long as there is an increase in height of at least 1 cm per 6 months or 2 cm per year