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Full article: Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12 n.d Accessed 21 Jun 2023 Felder CC, Briley EM, Axelrod J, Simpson JT, Mackie K

By influencing pathways involved in blood flow, cell migration, and soft tissue healing, they may help support recovery in areas such as tendons, ligaments, and muscles

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2.2 GIPR agonism serves to reduce GLP-1R mediated GI AEs in the clinic Treatment with GLP-1R agonists can drive nausea, diarrhea, vomiting, and constipation, which often results in discontinuation of treatment (6-10% of patients) or reduction in dose (~15% of patients) (63)

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