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Other studies have demonstrated that polyphenols are more stable in organic solvents and water than in cell culture media, where they degrade more rapidly ( Generally, most dietary polyphenols undergo hydrolysis by colonic bacteria and are then methylated and conjugated into glucuronide and sulfate metabolites by the hepatic and other tissues ( in vitro assays, whereas the crude blueberry extract demonstrated greater antioxidant effectiveness in in vivo models

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