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This 80% increase, observed in third-trimester pregnant women was estimated to occur throughout the entire pregnancy.[] This means **43% MORE of the toxic NAPQI metabolite is produced** during pregnancy compared to non-pregnant women

Figure 3 ThMP kinase, which produces ThDP through ThMP phosphorylation and is known in thiamine-synthesizing organisms, has not been identified in animals

Zhang Z, Zheng Y, Chen N, Xu C, Deng J, Feng X, et al

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Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggests neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease

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