Raziskan zaradi potencialnih uinkov na srno-ilni sistem
For a drug administered orally, bioavailability may be less than 100% for two main reasonsincomplete extent of absorption across the gut wall and first-pass elimination by the liver (see below)
Genome Res 14:18061811 Prabhakar R, Vreven T, Morokuma K, Musaev DG (2005) Elucidation of the mechanism of selenoprotein glutathione peroxidase (GPx)-catalyzed hydrogen peroxide reduction by two glutathione molecules: a density functional study
Cell 169.1 (2017): 132-147.e16
Without FDA approval, there are no standardized manufacturing processes, no official dosing guidelines, and no verified therapeutic claims
Given this situation it is particularly concerning that MDA campaigns show that PZQ cure rates are often less than 50% and modeling studies demonstrating that these campaigns with PZQ alone are unlikely to interrupt transmission, and once MDA is suspended, the prevalence of infection is likely to rebound to pre-MDA levels 9,10,11
