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When Synthetic HGH May Be Necessary Synthetic HGH may be more appropriate for patients with: Documented severe growth hormone deficiency (IGF-1 below normal range) Pituitary damage or dysfunction Failed stimulation test results Specific medical conditions requiring direct hormone replacement Failure to respond adequately to Sermorelin stimulation Severe symptoms requiring faster intervention These situations require thorough diagnostic testing and careful medical evaluation, which we provide through our in-house laboratory at our Edina location