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Scientific investigation focuses on the potential of this multi-pathway approach to optimize the structural integrity of the dermal barrier and minimize oxidative stress in complex tissue culture environments

This NAD+ elevation activates sirtuins, particularly SIRT1 in adipocytes and hepatocytes, which deacetylates and activates numerous metabolic regulatory proteins including PGC-1, a master regulator of mitochondrial biogenesis, oxidative metabolism, and thermogenesis

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37 , e00265-17 (2017)