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As a classic ligand of the Wnt/-catenin signaling pathway, Wnt3a suppresses adipogenic differentiation of MSCs via the downregulation of peroxisome proliferator-activated receptor (PPAR) and CCAAT/enhancer-binding protein (C/EBP) (152), thereby playing a crucial role in protecting against bone loss and regulating lipid metabolism in OVX rats

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To test if this mechanism was at play upon depleting GSH in the liver, we treated Gclc L-KO mice with T0901317, an LXR agonist