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Supplemental Material Figures S1S5 Tables S1S8 Nonstandard Abbreviations and Acronyms ACE angiotensin-converting enzyme ASCVD atherosclerotic cardiovascular disease CAD coronary artery disease CKD chronic kidney disease CRP C-reactive protein CVOT cardiovascular outcomes trial GLP-1 RA glucagon-like peptide-1 receptor agonist HbA1c glycated hemoglobin HR hazard ratio LDL low-density lipoprotein MACE major adverse cardiovascular event SGLT2i sodium-glucose cotransporter-2 inhibitor SOUL Semaglutide Cardiovascular Outcomes Trial T2D type 2 diabetes This manuscript was sent to Jennifer Green, Guest Editor, for review by expert referees, editorial decision, and final disposition