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Osthole regulates microRNA-22-3p-mediated lipid metabolic reprogramming, reduces serum total cholesterol and triglyceride/high-density lipoprotein cholesterol ratio, inhibits fatty acid transporters such as CD36 and fatty acid synthase (FAS), decreases fatty acid uptake, synthesis, and oxidation, and alleviates pulmonary vascular remodeling in PAH (Niu et al., 2022)