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Treatment with semaglutide reduced the risk of the composite endpoint of cardiovascular death or worsening heart failure events compared to placebo

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This idea, called the Carbohydrate-Insulin Model (CIM), is detailed in a paper by Ludwig et al (2021)

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Systemic side effects have not been a prominent feature in the existing research

It does this by activating the GH axis, which leads to a downstream increase in systemic growth hormone levels