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The medication's effects are primarily functional rather than reparative

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Nirao Shah, MD, PhD, a professor of psychiatry, behavioral sciences and neurobiology at Stanford University School of Medicine

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This fragmentation leads to high abandonment rates, where up to 64% of patients stop therapy within a year due to unmanaged side effects

PDK4 is highly responsive (activated) to an increased NADH/NAD + , whereas, PDK2 is much less sensitive to this activation