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a concentration above 140 ng/mL indicates adequate folate status.4 The enzyme dihydrofolate reductase is responsible for the conversion of dietary folate to tetrahydrofolate and is controlled by the DHFR gene

Search databases: a systematic search will be conducted across four major databases: PubMed, Web of Science Core Collection, Embase, and Cochrane Library

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That exceeds the results from every other weight loss medication tested in clinical settings, including Tirzepatide at 20.9% and Semaglutide at 14.9%

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