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The Cardio Conundrum Imagine you go to the gym and spend 45 minutes on the treadmill

Yet the track record of anti-obesity medications to date has been uniformly disappointing, notes Dr

doi:10.1158/1078-0432.CCR-12-0110

Safety Considerations and UK Regulatory Status Retatrutide is not MHRA-approved, meaning self-use outside clinical trials carries risks including product impurity, incorrect dosing, gastrointestinal adverse effects, and no pharmacovigilance oversight

That changed in early 2026