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Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3,5-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling

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26 There are several ways to design around these patents via 505(b)(2): Different Maintenance Doses : If the innovators patent specifies a maintenance dose of about 2.4 mg, a 505(b)(2) applicant might seek approval for a 2.0 mg or 3.0 mg dose supported by independent clinical data