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Challenges like low selectivity, potential off-target effects, and incomplete mechanism insights explain why DYRK1A inhibitors, despite encouraging in vitro and animal model outcomes, have not advanced to clinical trials for diabetes therapy (Wang et al

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Our findings demonstrate significant reductions in mortality, MAKE, and MALO across diverse patient populations, suggesting that this therapeutic approach could represent a paradigm shift in MASLD management

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The short half-life of native GLP-1 and advances in biochemical engineering led to the development of GLP-1 receptor agonists (GLP-1RAs)