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In the UK, NICE technology appraisals (TA875 for semaglutide and TA664 for liraglutide) specify that these treatments should be prescribed within specialist weight management services, with continuation dependent on achieving at least 5% weight loss at specified timepoints

Arch Pharm Res 42:383392

GCs from EMS patients exhibited lower expression of not just 3-HSD, but also CYP19, as well as impaired ability to release inhibin B and estrogen (79, 86, 87)

Semaglutide and tirzepatide share similar side effects, but studies show that semaglutide can cause higher rates of vomiting, constipation, and fatigue