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Likewise, decoding the accumulative mutation pattern based on MM patient samples will pave the path to the generation of MM transgenic mice model, which not only contribute to understanding the pathogenesis of MM but also serve as functional tools to evaluate the efficacy of novel therapeutic modalities

Sieverling, L

For instance, systemic administration of iron chelators such as deferoxamine or deferasirox effectively reduces Fe + levels and lipid peroxidation but carries the risk of disrupting systemic iron metabolism, potentially causing anemia, immune dysfunction, and impaired wound healing (53, 196, 197)

Zhou, M., Wang, H., Zhu, S., Liu, Y., & Xu, J

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Interestingly, an antagonist of MC-4R had an opposite effect, suggesting that MC-4R activation by MT-2 influences preference for alcohol