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[10] Long-term use of proton pump inhibitors (PPIs) and H2-receptor antagonists reduces gastric acid, potentially impairing the release of B12 from dietary proteins

A deficiency can lead to brittle nails, hair loss, and skin issues

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Evidence in this area is growing but not as robust as for skin applications

Once-daily dosing offers simplicity and better compliance, while split dosing theoretically maintains more stable tissue concentrations throughout the day

GLP- 1/oestradiol conjugate was more effective than GLP- 1 alone and triggered the insulin signaling pathway in beta cells, which led to remission of DM and restoration of beta cell function [140]